Fmr1 - fragile X messenger ribonucleoprotein 1

Enables several functions, including RNA binding activity; enzyme binding activity; and translation regulator activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of transport; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Part of polysome. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic cytosol. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of childhood onset epileptic encephalopathy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to human FMR1 (FMRP translational regulator 1). [provided by Alliance of Genome Resources, Apr 2022]