Lamp2 - lysosomal-associated membrane protein 2

Predicted to enable enzyme binding activity and protein domain specific binding activity. Involved in chaperone-mediated autophagy. Acts upstream of or within protein targeting to lysosome involved in chaperone-mediated autophagy. Located in endosome; lysosomal matrix; and lysosomal membrane. Colocalizes with membrane raft. Used to study Danon disease; cholestasis; chronic conjunctivitis; cognitive disorder; and hypertrophic cardiomyopathy. Biomarker of myocardial infarction and sciatic neuropathy. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]