Abcb4 - ATP binding cassette subfamily B member 4

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in response to glucocorticoid and response to xenobiotic stimulus. Located in Golgi membrane and apical plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]