Bcl2l1 - Bcl2-like 1

Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and positive regulation of transport. Located in cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; mental depression; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); pancreatic cancer; and stomach cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Apr 2022]