Enables triose-phosphate isomerase activity. Involved in carbohydrate metabolic process. Located in cytosol and nucleus. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]