Tg - thyroglobulin

Enables several functions, including anion binding activity; chaperone binding activity; and identical protein binding activity. Involved in several processes, including response to lipopolysaccharide; thyroid hormone generation; and transcytosis. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypothyroidism and isolated growth hormone deficiency. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Apr 2022]