Syp - synaptophysin

Enables protein domain specific binding activity and syntaxin-1 binding activity. Involved in endocytosis; regulation of opioid receptor signaling pathway; and response to amyloid-beta. Located in several cellular components, including excitatory synapse; postsynaptic density; and synaptic vesicle membrane. Part of protein-containing complex. Is integral component of synaptic vesicle membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Apr 2022]