Sod2 - superoxide dismutase 2

Enables several functions, including identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of membrane hyperpolarization; and positive regulation of hydrogen peroxide biosynthetic process. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]