Enables histone deacetylase binding activity; nucleic acid binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including animal organ development; positive regulation of intracellular signal transduction; and response to vitamin A. Located in dendrite; nucleus; and perinuclear region of cytoplasm. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]