Ptpn1 - protein tyrosine phosphatase, non-receptor type 1

Enables insulin receptor binding activity; protein phosphatase 2A binding activity; and protein tyrosine phosphatase activity. Involved in protein dephosphorylation and regulation of insulin receptor signaling pathway. Located in cytoplasmic vesicle; cytosol; and mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]