Prnp - prion protein

Enables several functions, including ATP-dependent protein binding activity; chaperone binding activity; and lamin binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Located in cytoplasm; plasma membrane; and postsynaptic density. Used to study hyperglycemia and scrapie. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein). [provided by Alliance of Genome Resources, Apr 2022]