Pklr - pyruvate kinase L/R

Enables pyruvate kinase activity. Involved in several processes, including cellular response to organonitrogen compound; pyruvate metabolic process; and response to purine-containing compound. Located in cytosol. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]