Rattus Norvegicus
Pkd1 - polycystin 1, transient receptor potential channel interacting
Basic Information
Predicted to enable several functions, including Wnt-activated receptor activity; protein kinase binding activity; and transmembrane transporter binding activity. Predicted to contribute to calcium channel activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in Golgi apparatus and lateral plasma membrane. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Apr 2022]
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Basic Information
NCBI
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Pkd1 Genetics information (Positive Sense)
- Chr
Sequence Homology
Humans, mice, and rats have highly similar genes, making them important for disease research and drug development. By studying their gene relationships, researchers can develop effective treatments for both humans and animals. Gene homology among these organisms allows for the translation of animal experimental results to humans, improving disease treatment and prevention.
Orthologs:
No Orthologs
Transcripts & Proteins
Transcripts are RNA molecules that are created during DNA transcription, and the translation products of these transcripts are proteins that serve numerous roles in the body. Transcripts and proteins are both important in biological research. The research of transcripts can help us uncover the subtle links between genes and illnesses, whereas the study of proteins can help us understand the processes of cellular function and disease etiology, as well as give prospective treatment targets.
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* This data comes from NCBI.
Gene Expression
The level of gene activity in a particular tissue or cell can be identified by its expression. Understanding the physiological processes and disease causes of organisms depends heavily on the specificity of gene expression levels in various tissues or cells. A thorough examination of the tissue and cell specificity of gene expression will contribute to the understanding of the genetic basis of disease and offer novel approaches to both prevent and cure disease.
Tissue-specific RNA expression
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Cell-specific RNA expression
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Protein Interaction
Protein-protein interaction is when two or more proteins bind together to perform their functions. It plays a vital role in most biochemical processes, such as signal molecules transmitting signals between cells. Molecular machines within the cells perform important functions through protein-protein interactions.
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References
Within the biological sciences, gene-related research literature is a valuable and essential resource. They meticulously document the composition, operation, and interaction of genes, giving us important hints to solve the enigmas surrounding life.
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