Serpina1 - serpin family A member 1

Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of serine-type endopeptidase activity; response to estradiol; and response to methanol. Located in extracellular space. Used to study pulmonary hypertension. Biomarker of asthma; osteoarthritis; pancreatitis (multiple); primary hyperaldosteronism; and proteinuria. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; chronic obstructive pulmonary disease (multiple); human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Apr 2022]