Abcb1b - ATP-binding cassette, subfamily B (MDR/TAP), member 1B

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; animal organ development; and cellular response to external biotic stimulus. Located in Golgi membrane and external side of apical plasma membrane. Used to study brain disease (multiple); colorectal adenocarcinoma; end stage renal disease; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]