Lmbrd1 - LMBR1 domain containing 1

Predicted to enable AP-2 adaptor complex binding activity; clathrin heavy chain binding activity; and insulin receptor binding activity. Predicted to be involved in gastrulation; protein localization to lysosome; and receptor-mediated endocytosis. Predicted to act upstream of or within negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; and negative regulation of protein kinase B signaling. Predicted to be located in several cellular components, including clathrin-coated endocytic vesicle; endoplasmic reticulum membrane; and lysosome. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblF. Orthologous to human LMBRD1 (LMBR1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]