Npr1 - natriuretic peptide receptor 1

Enables guanylate cyclase activity. Involved in several processes, including cGMP-mediated signaling; negative regulation of smooth muscle cell proliferation; and positive regulation of cGMP-mediated signaling. Located in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]