Nos1 - nitric oxide synthase 1

Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including blood vessel diameter maintenance; regulation of cation transmembrane transport; and regulation of neuron death. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]