Nf1 - neurofibromin 1

Enables microtubule binding activity and syndecan binding activity. Involved in several processes, including Schwann cell differentiation; cellular response to dexamethasone stimulus; and cellular response to nerve growth factor stimulus. Located in several cellular components, including axon; dendrite; and postsynaptic density. Part of protein-containing complex. Biomarker of sciatic neuropathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autistic disorder; hematologic cancer (multiple); nervous system cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]