Iqsec2 - IQ motif and Sec7 domain 2

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; modulation of chemical synaptic transmission; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in presynaptic active zone cytoplasmic component. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and postsynaptic density. Is expressed in brain. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2). [provided by Alliance of Genome Resources, Apr 2022]