Igf2 - insulin-like growth factor 2

Predicted to enable protein serine/threonine kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Apr 2022]