Htr1a - 5-hydroxytryptamine receptor 1A

Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and regulation of secretion. Located in axon hillock. Is active in GABA-ergic synapse. Is integral component of presynaptic membrane. Used to study Parkinson's disease and panic disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]