Disc1 - disrupted in schizophrenia 1

Enables molecular adaptor activity. Involved in several processes, including TOR signaling; nervous system development; and regulation of synapse maturation. Acts upstream of or within several processes, including mitochondrial calcium ion homeostasis; non-motile cilium assembly; and positive regulation of ubiquitin-dependent protein catabolic process. Located in microtubule organizing center; postsynaptic density; and synaptic vesicle. Is expressed in several structures, including brain; heart; liver; lung; and muscle tissue. Used to study endogenous depression and schizophrenia. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]