Grm2 - glutamate metabotropic receptor 2

Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in several processes, including behavioral response to nicotine; glutamate secretion; and regulation of amine transport. Acts upstream of or within regulation of protein kinase B signaling. Located in astrocyte projection; axon; and presynaptic membrane. Is integral component of postsynaptic membrane. Used to study heroin dependence. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Apr 2022]