Nr3c1 - nuclear receptor subfamily 3, group C, member 1

Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to magnesium ion; chromatin organization; and response to glucocorticoid. Located in cytoplasm; dendritic spine; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with nucleus. Used to study several diseases, including asthma; congestive heart failure; hypertension; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including brain disease (multiple); end stage renal disease; muscular atrophy; polycystic ovary syndrome; and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]