Chd2 - chromodomain helicase DNA binding protein 2

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone binding activity. Involved in muscle organ development. Acts upstream of or within cellular response to DNA damage stimulus and hematopoietic stem cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study CHARGE syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human CHD2 (chromodomain helicase DNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]