Got1 - glutamic-oxaloacetic transaminase 1

Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and ion homeostasis. Located in axon terminus; cytosol; and lysosome. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]