Gad2 - glutamate decarboxylase 2

Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in glutamate decarboxylation to succinate and response to xenobiotic stimulus. Located in several cellular components, including inhibitory synapse; perinuclear region of cytoplasm; and synaptic vesicle membrane. Is anchored component of membrane. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Apr 2022]