G6pd - glucose-6-phosphate dehydrogenase

Enables NADP binding activity; glucose binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; pentose-phosphate shunt, oxidative branch; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Located in cytosol and nucleus. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); hepatic encephalopathy; hyperhomocysteinemia; obesity; and phenylketonuria. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]