Chrm2 - cholinergic receptor, muscarinic 2, cardiac

Enables G protein-coupled acetylcholine receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within G protein-coupled acetylcholine receptor signaling pathway. Is active in cholinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; heart; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Apr 2022]