Egr1 - early growth response 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of macromolecule metabolic process; and regulation of synaptic plasticity. Located in cytoplasm and nucleus. Biomarker of several diseases, including liver cirrhosis; lung disease (multiple); middle cerebral artery infarction; pulmonary hypertension; and visual epilepsy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]