Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2

Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to nutrient levels; response to peptide hormone; and steroid biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]