Casr - calcium-sensing receptor

Enables integrin binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; and cellular chemical homeostasis. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]