Camk2b - calcium/calmodulin-dependent protein kinase II beta

Enables calmodulin-dependent protein kinase activity; phospholipase binding activity; and protein kinase binding activity. A structural constituent of postsynaptic actin cytoskeleton. Involved in several processes, including cellular response to homocysteine; hippocampal neuron apoptotic process; and regulation of synapse organization. Acts upstream of or within long-term synaptic potentiation. Located in dendrite and perikaryon. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 54. Orthologous to human CAMK2B (calcium/calmodulin dependent protein kinase II beta). [provided by Alliance of Genome Resources, Apr 2022]