Cacna1c - calcium voltage-gated channel subunit alpha1 C

Enables several functions, including high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and transmembrane transporter binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Located in several cellular components, including T-tubule; postsynaptic density; and synaptic membrane. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]