Atp7b - ATPase copper transporting beta

Enables copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Used to study Wilson disease; hepatitis; hepatocellular carcinoma; liver carcinoma; and renal adenoma. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]