Atp2b2 - ATPase plasma membrane Ca2+ transporting 2

Enables several functions, including ATP binding activity; P-type calcium transporter activity; and PDZ domain binding activity. Involved in brain development and neural retina development. Located in several cellular components, including apical plasma membrane; neuronal cell body membrane; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]