Atp1a3 - ATPase Na+/K+ transporting subunit alpha 3

Enables D1 dopamine receptor binding activity and amyloid-beta binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to retinoic acid; and metal ion transport. Located in several cellular components, including axon; dendritic spine; and myelin sheath. Part of sodium:potassium-exchanging ATPase complex. Is active in calyx of Held and postsynapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]