Frem2 - Fras1 related extracellular matrix protein 2

Predicted to enable metal ion binding activity. Involved in eye development. Acts upstream of or within animal organ development; embryonic digit morphogenesis; and morphogenesis of an epithelium. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; intraembryonic coelom; sensory organ; and skin. Used to study Fraser syndrome and isolated cryptophthalmia. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2). [provided by Alliance of Genome Resources, Apr 2022]