Adra2b - adrenoceptor alpha 2B

Enables alpha2-adrenergic receptor activity. Involved in several processes, including female pregnancy; positive regulation of MAPK cascade; and regulation of smooth muscle contraction. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]