Add1 - adducin 1

Enables T cell receptor binding activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of actin filament polymerization; and positive regulation of angiogenesis. Located in dendritic spine; perinuclear region of cytoplasm; and postsynaptic density. Used to study hypertension. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Apr 2022]