Enables neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; and pituitary adenylate cyclase-activating polypeptide receptor binding activity. Involved in several processes, including negative regulation of acute inflammatory response; positive regulation of cell communication; and regulation of GTPase activity. Located in extracellular space and terminal bouton. Used to study Parkinsonism and acute necrotizing pancreatitis. Biomarker of cystitis. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]