Lrrc8a - leucine rich repeat containing 8A VRAC subunit A

Predicted to enable cyclic-GMP-AMP transmembrane transporter activity; identical protein binding activity; and volume-sensitive anion channel activity. Predicted to contribute to anion channel activity. Predicted to be involved in several processes, including anion transport; cell volume homeostasis; and protein hexamerization. Predicted to act upstream of or within cell differentiation; ion transport; and spermatogenesis. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of lysosomal membrane and integral component of plasma membrane. Predicted to be part of ion channel complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Apr 2022]