Sufu - SUFU negative regulator of hedgehog signaling

Enables beta-catenin binding activity. Acts upstream of with a negative effect on smoothened signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]