Spry4 - sprouty RTK signaling antagonist 4

Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of MAP kinase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; germ layer; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Apr 2022]