Ets1 - E26 avian leukemia oncogene 1, 5' domain

Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]