Zfp458 - zinc finger protein 458

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF43 (zinc finger protein 43); and ZNF493 (zinc finger protein 493). [provided by Alliance of Genome Resources, Apr 2022]