Enables calcium, potassium:sodium antiporter activity; calcium-dependent protein binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to high light intensity; cone photoresponse recovery; and ion transmembrane transport. Acts upstream of or within positive regulation of gene expression. Located in several cellular components, including cone photoreceptor outer segment; plasma membrane; and vesicle. Is active in apical plasma membrane. Is expressed in several structures, including central nervous system; eye; stomach; testis; and thymus. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5. Orthologous to human SLC24A4 (solute carrier family 24 member 4). [provided by Alliance of Genome Resources, Apr 2022]