Phgdh - 3-phosphoglycerate dehydrogenase

Predicted to enable phosphoglycerate dehydrogenase activity. Acts upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Located in myelin sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]