Setd2 - SET domain containing 2

Enables histone methyltransferase activity (H3-K36 specific). Involved in endodermal cell differentiation; histone H3-K36 trimethylation; and stem cell differentiation. Acts upstream of or within several processes, including animal organ development; peptidyl-lysine methylation; and tube morphogenesis. Located in chromosome and nucleus. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; 8-cell stage embryo; and inner cell mass. Human ortholog(s) of this gene implicated in carcinoma (multiple); gastrointestinal system cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]